The approved products for systemic delivery via the lungs for diseases of the central nervous system and insulin for diabetes are also discussed. These are followed by sections on inhaled prostacyclins for pulmonary arterial hypertension and the challenging field of aerosol surfactant inhalation delivery, especially for prematurely born infants on ventilation support. Two “mucoactive” products-dornase α and mannitol, which are both approved for patients with cystic fibrosis-are reviewed. The antiviral and antibacterial inhaled products to treat respiratory tract infections are then presented. Products for asthma and chronic obstructive pulmonary disease include β-2 receptor agonists, muscarinic acetylcholine receptor antagonists, glucocorticosteroids, and cromones as well as their combinations. The organization of these sections reflects the key pharmacological categories. After general comments on the rationale for inhaled therapies for respiratory disease, the focus is on products approved approximately over the last half a century. After studying mechanical engineering at the University of Stuttgart, he worked at Trumpf Group, Ditzingen, in different areas from 1996 until 2014, whereof the last 6 years in Singapore in charge of various markets in Asia.The purpose of this review is to summarize essential pharmacological, pharmaceutical, and clinical aspects in the field of orally inhaled therapies that may help scientists seeking to develop new products. Hans-Peter Laubscher brings several years of experience in the international sale of machinery and plant to his new post. Hans-Peter Laubscher (51) becomes managing sales director at Kohler Maschinenbau GmbH in Lahr in the Black Forest, Germany. The entire system consisting of a decoiler, levelling machine, strip loop, slitting shears, dancer roller and recoiler will be used to produce ventilation and speaker covers made out of stainless steel. This is one reason why one of the leading full-service suppliers for the global automotive industry has decided to rely on a slitting unit from the Competence Center for Levelling Technology. For decades KOHLER has been one of the most reliable partners in the industry for the entire levelling process including the required peripherals, with more than 6,000 levelling machines built.
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May 2023
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